- 作者：Josep Rodrí ; guez Tolrà ; ; jrtol@wanadoo.es ; Arturo Domí ; nguez Garcí ; a ; Josep Torremadé ; Barreda ; Daniel Rodrí ; guez Pé ; rez ; Eladio Franco Miranda
- 关键词：Testosterona total ; Testosterona libre calculada ; Sí ; ndrome de dé ; ficit de testosterona
- 刊名：Revista Internacional de Androlog铆a
- 出版年：2010
- 期刊代码：pca322_1698031X
- 类别：med
- 出版时间：April-June 2010
- 卷：8
- 期：2
- 页码：85-88
- 文件大小：70 K
Objective
To demonstrate that calculated free testosterone is the optimal parameter for early diagnosis of testosterone deficiency syndrome and should be determined at the first visit.
Material and methods
From August 2007 to December 2009, we evaluated 203 patients with sexual health problems. In all patients, total testosterone, sex hormone-binding globulin (SHBG) and albumin serum-levels were measured at the first visit to calculate free testosterone levels.
Results
A total of 203 patients were studied. Calculated serum free testosterone levels were below 250 pmol/L in 80 patients who were candidates for testosterone replacement therapy. Among these, total serum testosterone levels were higher than 12 nmol/L in 24 patients (30%), between 8 and 12 nmol/L in 37 patients (46.3%) and below 8 nmol/L in 19 patients (23.8%). Interestingly, patients with a total serum testosterone level higher than 12 nmol/L had a calculated free testosterone level below 250 pmol/L due to high serum SHBG levels (mean value: 53.5 nmol/L).
Conclusions
This study indicates that calculated free testosterone level is more effective than total testosterone level for the early diagnosis of testosterone deficiency syndrome. Consequently, we propose that total testosterone, SHBG and albumin levels be measured at the first visit in order to determine free testosterone levels.