Serotonin transporter gene polymorphism (5-HTTLPR) in patients with oral lichen planus
- 作者：Paô ; lla Freitas Perdigã ; o ; André ; Luiz Sena Guimarã ; es ; Junia Maria Netto Victoria ; Guilherme Machado Xavier ; Marco Auré ; lio Romano-Silva ; Ricardo Santiago Gomez
- 关键词：5-HTTLPR ; Oral lichen planus and stress
- 刊名：Archives of Oral Biology
- 出版年：2007
- 期刊代码：25_00039969
- 类别：med
- 出版时间：September 2007
- 卷：52
- 期：9
- 页码：889-893
- 文件大小：162 K
摘要
Considerable evidence indicates that serotonergic mechanisms, particularly the serotonin transporter (5-HTT) may be involved in psychiatric alterations. Recent findings have demonstrated that depression and stress are influenced by polymorphism of the promoter region of 5-HTT (5-HTTLPR) and that the short allele (S) is associated with reduced transcriptional efficiency resulting in reduced serotonin expression and uptake. As psychiatric and genetic factors have been implicated in the pathogenesis of oral lichen planus (OLP), the purpose of the present study was to investigate 5-HTTLPR polymorphism in patients with OLP compared to control subjects.
Subjects and methods
Fifty-four subjects affected by OLP and 54 healthy volunteers were genotyped at 5-HTTLPR. The chi-squared test was used for statistical analysis. To investigate the association between the single nucleotide polymorphisms and risk of OLP, binary logistic regression models were fitted.
Results
No statistical difference was observed between the genotype and allele frequency in the group of OLP and controls (p = 0.51). Moreover no association between 5HTTLPR alleles and OLP was found in the multivariate analyses.
Conclusion
Our study demonstrates that polymorphism on the 5-HTTLPR is not associated with OLP pathogenesis.