Hippocampal c-Fos activation in normal and LPA₁-null mice after two object recognition tasks with different memory demands

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• 作者：Estela Castilla-Ortegap>ap> ; Carmen Pedrazap>ap> ; Jerold Chunp>bp> ; Fernando Rodr&iacute ; guez de Fonsecap>cp> ; Guillermo Estivill-Torrú ; sp>cp> ; Luis J. Sant&iacute ; np>ap>p> ; p>p>luis@uma.esp>
• 关键词：Early immediate gene ; Knockout ; Medial prefrontal cortex ; Temporal order memory ; Episodic-like memory
• 刊名：Behavioural Brain Research
• 出版年：2012
• 期刊代码：3_01664328
• 类别：neu
• 出版时间：1 July, 2012
• 卷：232
• 期：2
• 页码：400-405
• 文件大小：654 K

摘要

Normal and LPA₁-null mice, that have well reported hippocampal deficits, were assessed in an episodic-like what-when-where memory task or in a comparable task designed to test memory for familiar objects and locations by discriminating them from novels. Both genotypes performed the novelty recognition task but failed to learn the what-when-where task. However, normal mice showed what-when memory that was impaired in nulls. Each task elicited a different pattern of c-Fos expression. In normal mice, the what-when-where task induced more hippocampal c-Fos activation in the CA1 area than the novelty-based task, correlating with the what-when memory. LPA₁-null mice displayed a basal c-Fos hyperactivity in the hippocampus and in the medial prefrontal cortex, which was regulated differently by the two behavioural tasks employed. Both tasks were matched in exploratory behaviour and c-Fos activation in stress-related brain areas for both genotypes. This study shows that the what-when-where memory task differs from a comparable novelty-based task in both the learning demands and the neuronal correlates. Moreover, results also stress the role of the LPA₁ receptor in hippocampal functioning.