Impaired host defense to infection and Toll-like receptor 2-independent killing of Borrelia burgdorferi clinical isolates in TLR2-deficient C3H/HeJ mice

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• 作者：Wang ; Guiqing ; Ma ; Ying ; Buyuk ; Arzu ; McClain ; Steve ; Weis ; Janis J. ; Schwartz ; Ira
• 关键词：Borrelia burgdorferi ; Lyme disease ; Toll-like receptor 2 ; Innate immunity ; Animal disease model
• 刊名：FEMS Microbiology Letters
• 出版年：2004
• 期刊代码：34_03781097
• 类别：imm
• 出版时间：February 16, 2004
• 卷：231
• 期：2
• 页码：219-225
• 文件大小：341 K

摘要

To investigate the role of Toll-like receptor 2 (TLR2)-mediated signaling in host innate defense and development of Lyme disease, the pathogenicity of Borrelia burgdorferi sensu stricto clinical isolates representing two distinct genotypes (RST1 and RST3A) was assessed in TLR2^−/− C3H/HeJ mice. All TLR2^−/− mice infected with a B. burgdorferi RST1 isolate developed severe arthritis. The numbers of spirochetes in heart, joint and ear biopsy specimens were significantly higher in TLR2^−/− mice than in wild-type mice similarly infected as determined by real-time quantitative polymerase chain reaction. Interestingly, despite the higher spirochete levels in heart tissues, milder carditis was observed in TLR2^−/− than in wild-type mice infected with this RST1 isolate (P