VISA—A pass to innate immunity
- 作者：BaoChang Qi ; Yue Huang ; Dominic Rowe ; Glenda Halliday
- 关键词：VISA ; Mitochondria ; Viral infection ; Neurodegenerative disorders
- 刊名：The International Journal of Biochemistry and Cell Biology
- 出版年：2007
- 期刊代码：127_13572725
- 类别：med
- 出版时间：2007
- 卷：39
- 期：2
- 页码：287-291
- 文件大小：467 K
摘要
Virus-induced signaling adaptor (VISA) is essential for host innate immune responses against double-stranded RNA viral infection and viral replication. It is an adaptor that activates the transcription factors nuclear factor κB (NF-κB) and interferon regulatory factor 3 (IRF3) that regulate the expression of type I interferons. The localization of VISA to the outer membrane of mitochondria and the cellular consequences of its activation implicate this protein in the cellular etiology of neurodegenerative disorders.