Diarrhea Caused by Proton Pump Inhibitor Administration: Comparisons Among Lansoprazole, Rabeprazole, and Omeprazole

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• 作者：Shino Shimura ; MD¹ ; Naoharu Hamamoto ; MD ; PhD² ; Nagisa Yoshino ; MD ; PhD³ ; Yoshinori Kushiyama ; MD ; PhD⁴ ; Hirofumi Fujishiro ; MD ; PhD⁵ ; Yoshinori Komazawa ; MD ; PhD⁶ ; Kenji Furuta ; MD ; PhD¹ ; ^{kfuruta@med.shimane-u.ac.jp} ; Shunji Ishihara ; MD ; PhD¹ ; Kyoichi Adachi ; MD ; PhD⁷ ; Yoshikazu Kinoshita ; MD ; PhD¹
• 关键词：adverse effect ; collagenous colitis ; diarrhea ; loose bowels ; proton pump inhibitor
• 刊名：Current Therapeutic Research
• 出版年：2012
• 期刊代码：75_0011393x
• 类别：med
• 出版时间：June, 2012
• 卷：73
• 期：3
• 页码：112-120
• 文件大小：368 K

摘要

Background

The number of patients who require treatment with proton pump inhibitors (PPIs) is increasing in Japan. One of their adverse effects is diarrhea.

Objectives

We investigated the incidence of diarrhea caused by 3 different PPIs: lansoprazole, rabeprazole, and omeprazole.

Methods

Patients using PPIs for >1 month were enrolled. Enrolled patients recorded daily stool frequency, stool consistency using the Bristol Stool Scale Form, and impaired quality of life caused by diarrhea for 1 month. Their attending physicians described the types and dosages, and duration of PPI administration, as well as other necessary information.

Results

A total of 255 patients participated. Mean age of the patients was 70.7 years old. During the 1-month observation period, 3.5%of the patients complained of diarrhea. There was no significant difference for the incidence of diarrhea among the 3 types of PPIs. Furthermore, no correlations between diarrhea and length and dosage of PPI administration were found.

Conclusions

The incidence of diarrhea in patients receiving long-term therapy did not differ among 3 different PPIs. identifier: UMIN ID 000005300.