Synthesis of pyrrolophenanthridone alkaloid kalbretorine from indolecarboxylic acids via hypervalent iodine(III) mediated halodecarboxylation and reduction

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• 作者：Yasuyoshi Miki ; ^{y_miki@phar.kindai.ac.jp} ; Hideaki Umemoto ; Masashi Dohshita ; Hiromi Hamamoto
• 关键词：Decarboxylation ; Halogenation ; Hypervalent iodine ; Indolecarboxylic acids ; Pyrolophenanthridone alkaloid
• 刊名：Tetrahedron Letters
• 出版年：2012
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：11 April, 2012
• 卷：53
• 期：15
• 页码：1924-1927
• 文件大小：339 K

摘要

The treatment of 8,9,10-trimethoxy-7H-pyrrolo[3,2,1-de]phenanthridine-4,5-dicarboxylic acid with phenyliodine diacetate and potassium iodide in tetrahydrofuran gave the corresponding 4,5-diiodo derivative, which was converted to kalbretorine via reduction, demethylation, followed by alkylation.