Structure脙脙脙脙脙脙activity relationships and sub-type selectivity in an oxabicyclic estrogen receptor 脙脙脙脙/脙脙脙脙 agonist scaffold

详细信息	查看全文 | 推荐本文 |

• 作者：Hamann ; Lawrence G. ; Meyer ; J. Hoyt ; Ruppar ; Daniel A. ; Marschke ; Keith B. ; Lopez ; Francisco J. ; et. al.
• 关键词：Estrogen receptor ; Osteoporosis
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2005
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：March 1, 2005
• 卷：15
• 期：5
• 页码：1463-1466
• 文件大小：144 K

摘要

An oxabicyclic template for estrogen receptor 脦脦 and 脦脦 agonists has been identified which can be tuned to provide moderate levels of selectivity for either receptor sub-type. Structure脦脦脦activity relationships within this phenol-substituted oxabicyclo[3.3.1]nonene series are described. Select compounds from the present series showed activity in vivo after oral dosing in rodent models of uterine proliferation.