Preincisional peritonsillar vs. intravenous lornoxicam for posttonsillectomy analgesia: A clinical and platelet aggregometry comparative study

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• 作者：Hala Saad Abdel-Ghaffar^a ; ^{hallasaad@yahoo.com} ; Jehane Ahmed Sayed^a ; ^{Jehane.Alloul@yahoo.com} ; Mohamed Amir Fathy^b ; ^{Amir63@yahoo.com} ; Hanan Galal Abdel-Azeem^c ; ^{Hanahgalal2000@yahoo.com} ; Mohamed Ahmed Mahmoud Salem^d ; ^{drsalem70@yahoo.com}
• 关键词：Pediatric ; Tonsillectomy ; Analgesia ; NSAIDS ; Lornoxicam
• 刊名：Egyptian Journal of Anaesthesia
• 出版年：2012
• 期刊代码：pca120_11101849
• 类别：med
• 出版时间：April, 2012
• 卷：28
• 期：2
• 页码：107-115
• 文件大小：882 K

摘要

Background

Lornoxicam is a fairly new short-half oxicam with an improved tolerability profile. Our objective was to investigate the safety and efficacy of intravenous and peritonsillar infiltration of 8 mg lornoxicam on pain relief in children undergoing tonsillectomy.

Methods

In a double-blinded, placebo-controlled trial, 60 children were randomized into three groups; intravenous group (n = 20), received lornoxicam 8 mg iv., infiltration group (n = 20) received lornoxicam 8 mg peritonsillar infiltration, and placebo controls (n = 20). The verbal rating pain scale, time to first postoperative analgesic request, total analgesic consumption during 1st 24 h postoperative, platelet aggregometry before, 15 min, 2 and 24 h after study drug administration, intraoperative blood loss, postoperative bleeding, and adverse effects were evaluated.

Results

The time to first postoperative analgesic request was significantly prolonged in intravenous (318.75 卤 67.37 min) and infiltration (214.50 卤 43.06 min) groups compared with placebo group (66.75 卤 26.95 min). A significantly lower mean postoperative VRS scores and significantly reduced 1st day postoperative diclofenac consumption were recorded in iv. group (44.73 卤 9.31 mg), compared with infiltration (69.80 卤 38.71 mg) and placebo (87.8 卤 24.40 mg) groups. An increased intraoperative blood volume losses and intraoperative bleeding complains were observed in infiltration group (34.25 卤 11.93 ml), rather than in iv. (28.85 卤 10.01 ml) and placebo (24.75 卤 8.70 ml) groups. The (%) of platelet aggregation with ADP, collagen, and arachidonic acid was significantly reduced 15 min and 2 h after study drug administration with highest decreases in iv. group compared with infiltration and placebo groups. No patients reported postoperative bleeding or GIT adverse effects in the study.

Conclusion

Intraoperative preincisional intravenous lornoxicam enhanced postoperative analgesia after tonsillectomy in children. In comparison, the analgesic efficacy of locally applied lornoxicam was inferior to intravenous administration and was associated with increased incidence of intraoperative bleeding.