C8-alkynyl- and alkylamino substituted 2′-deoxyguanosines: a universal linker for nucleic acids modification

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• 作者：Yoshio Saito ; Katsuhiko Matsumoto ; Subhendu Sekhar Bag ; Shinzi Ogasawara ; Kenzo Fujimoto ; Kazuo Hanawa ; Isao Saito
• 关键词：LC MS/MS ; Stilbene ; Resveratrol ; Photoisomerisation ; 3 ; 4′ ; 5-Trihydroxy-diphenylacetylene
• 刊名：Tetrahedron
• 出版年：2008
• 期刊代码：107_00404020
• 类别：ch
• 出版时间：14 April 2008
• 卷：64
• 期：16
• 页码：3578-3588
• 文件大小：414 K

摘要

Incorporation of modified nucleosides with a flexible universal linker is of great value for post-synthetic modification of nucleic acids. Thus, C8-alkynyl- and alkylamino substituted 2′-deoxyguanosines were synthesized for the first time and incorporated into short oligonucleotide sequences. The preference for syn conformation of these C8-substituted 2′-deoxyguanosines and the stability of the duplexes were discussed. The stabilizing effect of Z-DNA has also been examined.