T.A. Woolsey, J. Hanaway and M.H. Gado, Editors, The Brain Atlas (third edition), Wiley, Hoboken, New Jersey, USA (2008) ISBN 978-0-470-08476-2 254 pages, US$ 60.

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• 作者：Arnulf H. Koeppen
• 关键词：Nitric oxide synthase ; Cyclooxygenase ; Xanthium strumarium ; Sesquiterpene ; Nuclear factor κ ; B
• 刊名：Journal of the Neurological Sciences
• 出版年：2008
• 期刊代码：178_0022510x
• 类别：med
• 出版时间：15 August 2008
• 卷：271
• 期：1-2
• 页码：214
• 文件大小：77 K

摘要

Three sesquiterpenoids, xanthatin (1), xanthinosin (2), and 4-oxo-bedfordia acid (3) were isolated from Xanthium strumarium as inhibitors of nitric oxide synthesis in activated microglia (IC₅₀ values: 0.47, 11.2, 136.5 μM, respectively). Compounds 1 and 2 suppressed the expression of iNOS and COX-2 and the activity of NF-κB through the inhibition of LPS-induced I-κB- degradation in microglia.