Tetrodotoxin does not protect red-spotted newts, Notophthalmus viridescens, from intestinal parasites

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• 作者：Dietrich Mebs^a ; ^{mebs@em.uni-frankfurt.de} ; Mari Yotsu-Yamashita^b ; Hanns Martin Seitz^c ; Osamu Arakawa^d
• 关键词：Tetrodotoxin ; 6-Epitetrodotoxin ; Newt ; Notophthalmus viridescens ; Intestinal parasites
• 刊名：Toxicon
• 出版年：2012
• 期刊代码：50_00410101
• 类别：pha
• 出版时间：July, 2012
• 卷：60
• 期：1
• 页码：66-69
• 文件大小：1066 K

摘要

Tetrodotoxin (TTX) and its analogue 6-epiTTX had been detected in the red-spotted newt, Notophthalmus viridescens. Thirty specimens of a population from Pennsylvania, USA were histologically examined for the presence of intestinal parasites. More than 50%were found to be infected with nematodes (Trichocephalidae), trematodes or cestodes (Pseudophyllidae). The mean values of TTX and 6-epiTTX in parasitized and in non-parasitized newts were not significantly different. Using a monoclonal antibody-based immunoenzymatic technique, TTX was localized in the intestinal tissue as well as in the parasites indicating that they accumulate the toxin and suggesting that TTX and 6-epiTTX are not providing protection from parasites to the newts.