Clinicopathologic and genetic studies of nasal NK/T-cell lymphoma: 2. Mutations of the p53, β-catenin, and ras genes
- 作者：Takahara ; Miki ; Kishibe ; Kan ; Bandoh ; Nobuyuki ; Nonaka ; Satoshi ; Harabuchi ; Yasuaki
- 关键词：Nasal NK/T-cell lymphoma ; p53 ; Ras ; Beta-catenin
- 刊名：International Congress Series
- 出版年：2003
- 期刊代码：297_05315131
- 类别：med
- 出版时间：October, 2003
- 卷：1240
- 期：Complete
- 页码：1141-1144
- 文件大小：61.0 K
摘要
The p53 is a well-known tumor suppressor gene that causes cell with damaged DNA to arrest cell cycle or promote apoptosis. Ras gene is a well-known oncogene, and its function is to switch from an inactive GDP-bound state to an active GTP-bound state after ligand interaction of a variety of extra cellular receptors. β-Catenin originally has a role in E-cadherin-mediated cell–cell adhesion, but its stabilization plays important role in carcinogenesis. There are many reports about mutations of the genes in various malignancies, but few report in nasal NK/T-cell lymphoma (N-NKTL). In this study, we analyzed mutations of the p53 and β-catenin gene in 32 cases of nasal NK/T-cell lymphoma.