^99mTc-NC100692 — a tracer for imaging vitronectin receptors associated with angiogenesis: a preclinical investigation

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• 作者：David Edwards ; Paul Jones ; Helena Haramis ; Mark Battle ; Rochelle Lear ; D Jon. Barnett ; Catherine Edwards ; Hazel Crawford ; Andrew Black ; Vanessa Godden
• 关键词：Angiogenesis ; Biodistribution ; Molecular imaging ; Vitronectin receptor ; ^99mTc-NC100692
• 刊名：Nuclear Medicine and Biology
• 出版年：2008
• 期刊代码：43_09698051
• 类别：ph
• 出版时间：April 2008
• 卷：35
• 期：3
• 页码：365-375
• 文件大小：544 K

摘要

Technetium 99m (^99mTc)-NC100692 is being developed as a marker of vitronectin receptor expression. The purpose of this study was to confirm the binding affinity [dissociation constant (Kd)] of ^99mTc-NC100692 for a range of integrin receptors including _vβ₃ and _vβ₅ as well as to establish the biodistribution and metabolic stability of ^99mTc-NC100692 in Wistar rats.