Heterogeneous transmural gene expression of calcium-handling proteins and natriuretic peptides in the failing human heart

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• 作者：Prestle ; Jü ; rgen ; Dieterich ; Sabine ; Preuss ; Michael ; Bieligk ; Ursula ; Hasenfuss ; Gerd
• 关键词：Human (Species) ; Experimental (Discipline) ; Heart (Object) ; Molecular biology (Level) ; Ca-pump ; Gene expression ; Heart failure ; Na/Ca-exchanger ; Natriuretic peptide
• 刊名：Cardiovascular Research
• 出版年：1999
• 期刊代码：48_00086363
• 类别：med
• 出版时间：August 1, 1999
• 卷：43
• 期：2
• 页码：323-331
• 文件大小：935 K

摘要

Objective: Human heart failure is associated with a disturbed intracellular calcium (Ca²⁺) homeostasis. In this regard, ventricular wall stress is considered to be a determinant for expression of sarcoplasmic reticulum Ca²⁺-ATPase (SERCA2a). In the present study, we analyzed the transmural protein and/or mRNA levels of SERCA2a, other Ca²⁺-handling proteins, and of atrial and brain natriuretic peptides (ANP and BNP) in the human heart. Methods: Subepicardial (epi), midmyocardial (mid), and subendocardial (endo) sections of the left ventricular free wall from end-stage failing (n