Diagnostic performance of breast MRI with and without the addition of quantitative diffusion weighted imaging

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• 作者：Reem Hassan Bassiouny ; ^{r_h_bassiouny@yahoo.com} ; Tarek Youssef ; Olaa Hassan
• 关键词：Diffusion weighted MRI ; Breast lesions ; Local recurrence at operative scar
• 刊名：The Egyptian Journal of Radiology and Nuclear Medicine
• 出版年：2012
• 期刊代码：pca124_0378603X
• 类别：med
• 出版时间：June, 2012
• 卷：43
• 期：2
• 页码：311-323
• 文件大小：1746 K

摘要

Objective

The purpose of our study was to investigate whether adding diffusion weighted imaging to dynamic contrast-enhanced MRI could improve the diagnostic performance of breast MRI.

Materials and methods

This retrospective study included 86 women with 93 primary and postoperative breast lesions detected on DCE-MRI who underwent subsequent biopsy. The diagnostic performance was calculated for DCE-MRI alone, combined DCE-MRI and quantitative DWI, and for quantitative DWI alone.

Results

Of the 93 lesions, 42 were benign and 51 malignant (5 DCIS, 41 IDC, 2 ILC, 3 NOS). Both DCIS (mean ADC = 1.17 卤 0.12 脳 10^鈭? mm²/s) and IDC (mean ADC, 0.98 卤 0.14) exhibited lower mean ADC values than benign lesions (ADC value = 1.72 卤 0.36). Applying an ADC cutoff value of 1.33 increased the specificity and PPV of DCE-breast MRI from 59.5%and 75%to 78.5%and 83.3%, respectively. The specificity and PPV for quantitative DW-MRI alone (73.5%and 83.3%) were close to those broken out from the combined use of DCE and quantitative DW-MRI. However, the sensitivity and NPV of DWI remains lower than that of DCE-MRI.

Conclusion

DWI shows potential for improving the diagnostic performance of breast MRI and may reduce the number of unnecessary biopsies.