Eighty five subjects at risk for type 2 diabetes were classified according to the presence of MS. Lipoprotein profile, HOMA-IR and endogenous CETP activity were evaluated.
As expected, MS patients presented higher concentration of glucose, insulin, triglycerides and non-HDL-C and lower HDL-C levels. Moreover, MS patients exhibited increased HOMA-IR and CETP activity. Employing a ROC curve for MS, high CETP activity was defined as > 250% ml鈭?#xA0;1 h鈭?#xA0;1. The predictive variables of high CETP were non-HDL-C 鈮?#xA0;160 mg/dl (OR = 11.1;95%IC = 3.3-38.2;p < 0.001) and HOMA-IR > 2.1 (OR = 4.4;95%IC = 1.3-14.8;p < 0.05).
High non-HDL-C and insulin resistance were predictors for increased CETP activity which measurement is not accessible for clinical laboratories.