Elevated anxiety-like and depressive behavior in Desert hedgehog knockout male mice
- 作者：Fujio Umehara ; Kenichi Mishima ; Nobuaki Egashira ; Ayumi Ogata ; Katsunori Iwasaki and Michihiro Fujiwara
- 关键词：Desert hedgehog ; Knockout mice ; Gonadal dysgenesis ; Testosterone ; Depression ; Anxiety
- 刊名：Behavioural Brain Research
- 出版年：2006
- 期刊代码：3_01664328
- 类别：neu
- 出版时间：1 November 2006
- 卷：174
- 期：1
- 页码：167-173
- 文件大小：183 K
摘要
To investigate the functional role of Desert hedgehog (Dhh) gene in the nervous system, we examined motor, sensory, learning and memory functions as well as mood in Dhh knockout (KO) mice. Dhh KO male mice exhibited prolonged immobility time compared with wild-type male mice in the forced swimming test, and showed enhanced inhibition in the Vogel's conflict model. These findings suggest that Dhh KO male mice exhibited enhanced anxiety and depressive behavior compared with wild-type male mice. In contrast, Dhh KO female mice did not show any significant difference compared to wild-type female mice. These behavioral abnormalities of Dhh KO male mice may be due to lower testosterone levels with abnormal development of the testes caused by Dhh-null mutation.