S100B-immunopositive glia is elevated in paranoid as compared to residual schizophrenia: A morphometric study
- 作者：Johann Steiner ; Hans-Gert Bernstein ; Hendrik Bielau ; Nadine Farkas ; Jana Winter ; Henrik Dobrowolny ; Ralf Brisch ; Tomasz Gos ; Christian Mawrin ; Aye Mu Myint ; Bernhard Bogerts
- 关键词：Schizophrenia ; Post-mortem ; Histopathology ; S100B ; S-100B ; S100 beta
- 刊名：Journal of Psychiatric Research
- 出版年：2008
- 期刊代码：169_00223956
- 类别：med
- 出版时间：August 2008
- 卷：42
- 期：10
- 页码：868-876
- 文件大小：461 K
摘要
Several studies have revealed increased S100B levels in peripheral blood and cerebrospinal fluid (CSF) of patients with schizophrenia. In this context, it was postulated that elevated levels of S100B may indicate changes of pathophysiological significance to brain tissue in general and astrocytes in particular. However, no histological study has been published on the cellular distribution of S100B in the brain of individuals with schizophrenia to clarify this hypothesis.