Rational design and synthesis of novel heparan sulfate mimetic compounds as antiadhesive agents

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• 作者：Ishida ; Keisuke ; Simizu ; Siro ; Teruya ; Takayuki ; Wierzba ; Michal K. ; Osada ; Hiroyuki
• 关键词：Drug design ; Antitumor ; Heparan sulfate mimetic
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2004
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：May 17, 2004
• 卷：14
• 期：10
• 页码：2505-2509
• 文件大小：434 K

摘要

A biological evaluation of the antiadhesive activity of novel heparan sulfate glycosaminoglycans mimetic compounds (KI-compounds) is described. In an adhesion assay, KI-111 [2-(4-fluoro-3-nitrobenzoyl)benzoic acetic anhydride] was found to exert potent inhibitory activities against the adhesion of human fibrosarcoma HT1080 cells and HeLa cells to fibronectin. Cell growth, migration, and invasion of HT1080 cells were also inhibited by KI-111 at almost equal concentrations.