• 作者：Consuelo Ferná ; ndez-Miranda^a ; ^{cf-miranda@hotmail.com} ; Marí ; a Luisa Manzano^b ; Inmaculada Ferná ; ndez^b ; Guadalupe Ló ; pez-Alonso^c ; Pilar Gó ; mez^d ; Rosa Ayala^d ; David Lora^e ; Gregorio Castellano^b
• 关键词：Hepatitis cr&oacute ; nica C ; Esteatosis hepá ; tica ; Hiperhomocisteinemia ; Alcohol ; Polimorfismo de la MTHFR-C677T
• 刊名：Medicina Cl铆nica
• 出版年：2011
• 期刊代码：pca254_00257753
• 类别：med
• 出版时间：29 January 2011
• 卷：136
• 期：2
• 页码：45-49
• 文件大小：183 K

Background and objectives

Liver steatosis in chronic hepatitis C (CHC) is related to viral and metabolic factors and likely to genetic factors. The aim of this study was to know if hyperhomocysteinemia and methylenetetrahydrofolate reductase (MTHFR)-C677T polymorphisms are associated with liver steatosis in nonalcoholic patients with CHC.

Patients and method

In 54 consecutive patients with CHC, alcohol consumption less than 40 g/week, and no other causes of liver disease, a liver biopsy was performed. All variables were obtained at the time of biopsy. MTHFR-C677T was also performed in 128 healthy subjects, with age and gender similar to the patients.

Results

Liver steatosis was found in 33 patients (61%), 30 of them having a mild degree. Hyperhomocysteinemia was more prevalent in patients with steatosis (61%vs 24%; p = 0.008) and overweight tended to be more prevalent in the same patients (61%vs 33%; p = 0.05). All patients with virus C genotype 3 had steatosis. Viral load, liver inflammatory and fibrosis score were not different in patients with and without steatosis. MTHFR-C677T polymorphism was similar in controls and cases and in cases with and without steatosis. A multiple logistic regression showed that hyperhomocysteinemia was associated with liver steatosis after adjustment for age and sex (OR: 3.94; 95%CI: 1.09-14.29), and adjustment for overweight (OR: 4.43; 95%CI: 1.27-15.51).

Conclusions

In nonalcoholic patients with CHC mild liver steatosis is frequent, and is associated with hyperhomocysteinemia. An association between steatosis and MTHFR-C677T polymorphism was not found.