• 作者：Emilio Ramos Rubio ; ^{eramos@bellvitgehospital.cat} ; ^{emilioramos@buhardillabis.jazztel.es} ; Laura Llado Garriga
• 关键词：Hepatocarcinoma ; Trasplante hepá ; tico ; Biopsia hepá ; tica
• 刊名：Cirug铆a Espa帽ola
• 出版年：2010
• 期刊代码：pca87_0009739X
• 类别：med
• 出版时间：March 2010
• 卷：87
• 期：3
• 页码：133-138
• 文件大小：136 K

The selection of patients with hepatocellular carcinoma (HCC) for liver transplantation must be improved. One of the methods proposed to achieve this objective consists of including predictors of tumour aggressiveness to the decision making algorithm. The procedures that would enable this characteristic to be assessed, are: 1. Serum biomarkers, 2. Response to transarterial chemoembolisation and 3. Data on the tumour histology. In this review, the available data on the usefulness of each of these procedures are analysed. Special attention is given to the evidence associated with the possible usefulness of a preoperative biopsy. It can be concluded that a preoperative biopsy could be useful to indicate liver transplantation in patients with extended criteria, but not in patients that fulfil the Milan criteria. This scenario could soon change if the initial data on the prognostic value of some molecular markers of tumour progression are confirmed.