Niemann-Pick C1-Like 1 and cholesterol uptake
- 作者：Li-Juan Wang ; Bao-Liang Song ; blsong@sibs.ac.cn
- 关键词：NPC1L1 ; Niemann&ndash ; Pick C1-Like 1 ; LDL ; low-density lipoprotein ; PM ; plasma membrane ; ERC ; endocytic recycling compartment ; NTD ; N-terminal domain ; NFC ; NPC1L1&ndash ; Flotillin&ndash ; Cholesterol
- 刊名：Biochimica et Biophysica Acta (BBA)/Molecular and Cell Biology of Lipids
- 出版年：2012
- 期刊代码：18_13881981
- 类别：bio
- 出版时间：July, 2012
- 卷：1821
- 期：7
- 页码：964-972
- 文件大小：916 K
摘要
Niemann-Pick C1-Like 1 (NPC1L1) is a polytopic transmembrane protein responsible for dietary cholesterol and biliary cholesterol absorption. Consistent with its functions, NPC1L1 distributes on the brush border membrane of enterocytes and the canalicular membrane of hepatocytes in humans. As the molecular target of ezetimibe, a hypocholesterolemic drug, its physiological and pathological significance has been recognized and intensively studied for years. Recently, plenty of new findings reveal the molecular mechanism of NPC1L1's role in cholesterol uptake, which may provide new insights on our understanding of cholesterol absorption. In this review, we summarized recent progress in these studies and proposed a working model, hoping to provide new perspectives on the regulation of cholesterol transport and metabolism.