Human manganese superoxide dismutase suppresses HER2/neu-mediated breast cancer malignancy
- 作者：Tzu-Chao Chuang ; Jah-Yao Liu ; Chi-Tsai Lin ; Ya-Ting Tang ; Ming-Han Yeh ; Su-Chien Chang ; Jhy-Wei Li ; Ming-Ching Kao
- 关键词：HER2/neu ; MnSOD ; Metastasis ; Breast cancers
- 刊名：FEBS Letters
- 出版年：2007
- 期刊代码：70_00145793
- 类别：bio
- 出版时间：18 September 2007
- 卷：581
- 期：23
- 页码：4443-4449
- 文件大小：272 K
摘要
The up-regulation of HER2/neu is associated with human malignancies and is a useful target for developing anticancer drugs. Overexpression of human manganese superoxide dismutase (MnSOD) has been demonstrated to effectively suppress various carcinoma cells, including breast carcinomas, in vitro and in vivo. This study demonstrates that MnSOD effectively suppresses HER2/neu oncogene expression at the transcriptional level. Additionally, stable transfection was used and the MnSOD-transfected human breast cancer clones were found to be able to down-regulate the endogenous production of p185HER2/neu. Furthermore, the MnSOD-overexpressing stable transfectants exhibited reduced soft-agarose colony-forming ability and metastatic properties, unlike control cell lines. These data suggest that MnSOD may be useful in treating HER2/neu-mediated human breast tumor malignancy.