Analysis of AGE modified proteins and RAGE expression in HER2/neu negative invasive ductal carcinoma

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• 作者：Arvind M. Korwar^a ; Hemangi S. Bhonsle^b ; Ashok D. Chougale^b ; Sachin S. Kote^b ; Kachru R. Gawai^a ; Vikram S. Ghole^a ; Chaitanyananda B. Koppikar^c ; Mahesh J. Kulkarni^b ; ^{mj.kulkarni@ncl.res.in}
• 关键词：Breast cancer ; Advanced glycation end products ; RAGE
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2012
• 期刊代码：159_0006291x
• 类别：bio
• 出版时间：16 March, 2012
• 卷：419
• 期：3
• 页码：490-494
• 文件大小：552 K

摘要

Cancer is associated with increased glycolysis and carbonyl stress. In view of this, AGE modified proteins were identified from clinical breast cancer tissue using 2DE-immunoblot and mass-spectrometry. These proteins were identified to be serotransferrin, fibrinogen gamma chain, glycerol-3-phosphate dehydrogenase, lactate dehydrogenase, annexin II, prohibitin and peroxiredoxin 6, which have established role in cancer. Further, RAGE expression and its downstream signaling proteins NADPH oxidase and NF-kB were studied. Role of these AGE modified proteins and RAGE signaling in breast cancer is discussed.