Resveratrol inhibits heregulin-β1-mediated matrix metalloproteinase-9 expression and cell invasion in human breast cancer cells
- 作者：Feng-Yao Tang ; En-Pei Isabel Chiang ; Ya-Chi Sun
- 关键词：Resveratrol ; Heregulin-β ; 1 ; Matrix metalloproteinase ; Mitogen-activated protein kinase ; Tissue inhibitor metalloproteinase protein ; Human breast cancer cells
- 刊名：Journal of Nutritional Biochemistry
- 出版年：2008
- 期刊代码：70_09552863
- 类别：abs
- 出版时间：May 2008
- 卷：19
- 期：5
- 页码：287-294
- 文件大小：672 K
摘要
The growth factor heregulin-β1 (HRG-β1), which is expressed in breast cancer, activates the HER-2 signaling pathway through induction of heterodimeric complexes of HER-2 with HER-3 or HER-4. It has been shown in many studies that HRG-β1 induces the tumorigenicity and metastasis of breast cancer cells. Matrix metalloproteinase (MMP) 9 is a key enzyme in the degradation of extracellular matrices, and its expression may be dysregulated in breast cancer invasion and metastasis. Resveratrol, a major component in grape, exhibited potential anticarcinogenic activities in both in vitro and in vivo studies. However, the inhibitory effect of resveratrol on HER-2-mediated expression of MMP-9 has not been demonstrated yet.