[1,3]Diazaheterofused isoindolol derivatives displaying anxiolytic-like effects on mice
- 作者：Alej ; ro Zamilpa ; Maribel Herrera-Ruiz ; Esther Del Olmo ; José ; L. Ló ; pez-Pé ; rez ; Jaime Tortoriello ; Arturo San Feliciano
- 关键词：Benzalphthalides ; Imidazo-isoindole ; Pyrimido-isoindole ; Diazepino-isoindole ; Structural– ; activity relationship (SAR) ; Anxiolytic effects ; Mice experiments ; Open arms test ; Elevated plus-maze test
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2007
- 期刊代码：10_0960894x
- 类别：ch
- 出版时间：15 July 2007
- 卷：17
- 期：14
- 页码：4016-4021
- 文件大小：212 K
摘要
Anxiolytic-like effects induced on mice by several compounds with imidazo[2,1-a]isoindolol (II), pyrimido[2,1-a]isoindolol (III) and [1,3]diazepino[2,1-a]isoindolol (IV) structures have been evaluated through the elevated plus-maze test. The evaluation has been based on measuring the spent time and counting the number of entries of mice in the open arms of the maze. Single intraperitoneal administration of imidazoisoindolol IIe and pyrimidoisoindolols IIIa, IIIe and IIIg induced significant increments in these behavioural parameters.