Hexylitaconic acid: A new inhibitor of p53–HDM2 interaction isolated from a marine-derived fungus, Arthrinium sp.

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• 作者：Sachiko Tsukamoto ; Takushi Yoshida ; Hidetaka Hosono ; Tomihisa Ohta and Hideyoshi Yokosawa
• 关键词：p53 ; HDM2 ; Ubiquitin ligase ; Marine-derived fungus ; Arthriniun sp
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2006
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：1 January 2006
• 卷：16
• 期：1
• 页码：69-71
• 文件大小：104 K

摘要

A new inhibitor of p53–HDM2 interaction was isolated from a culture of marine-derived fungus, Arthrinium sp. The structure was identified to be (−)-hexylitaconic acid (1) by spectroscopic analysis. The inhibition of p53–HDM2 binding was tested by the ELISA method, and 1 inhibited the binding with an IC₅₀ value of 50 μg/mL. Although a number of synthetic inhibitors of p53–HDM2 interaction have been reported so far, 1 is the second inhibitor isolated from natural resources.