Interleukin-13 stimulates the secretion of vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 by human oviductal epithelial cells

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• 作者：Hiroko Itoh ; Kaei Nasu ; Akitoshi Yuge ; Yasushi Kawano ; Jun Yoshimatsu ; Hisashi Narahara
• 关键词：Fallopian tube ; Vascular endothelial growth factor ; Soluble fms-like tyrosine kinase-1 ; Oviductal fluid ; Vascular permeability ; Interleukin-13
• 刊名：European Journal of Obstetrics and Gynecology and Reproductive Biology
• 出版年：2007
• 期刊代码：92_03012115
• 类别：med
• 出版时间：August 2007
• 卷：133
• 期：2
• 页码：208-212
• 文件大小：288 K

摘要

The aim of this study is to evaluate the effects of interleukin (IL)-13, a Th2 cytokine, on the production of vascular endothelial growth factor (VEGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) in human oviductal cells in vitro.

Study design

Human oviductal epithelial cells (OECs) were isolated from five premenopausal patients. The secretion of VEGF₁₆₅ and sFlt-1 by cultured OECs in response to IL-13 was measured using an enzyme-linked immunosorbent assay.

Results

The secretion of VEGF₁₆₅ and sFlt-1 was detected in cultured OECs under untreated conditions. IL-13 enhanced the secretion of VEGF₁₆₅ and sFlt-1 by OECs in a dose-dependent manner.

Conclusion

The present findings suggest that IL-13 is a regulatory factor of VEGF and sFlt-1 production in the human fallopian tubes. IL-13 in the local environment may stimulate oviductal vascular permeability by inducing the production of VEGF by oviductal cells. The modulation of VEGF secretion by IL-13 secreted by the peri-implantation embryo may contribute to the normal and pathological processes of human reproduction during the peri-implantation period.