Total synthesis of (±)-methyl-kinamycin C

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• 作者：Takuya Kumamoto ; Yasuo Kitani ; Hideyoshi Tsuchiya ; Kentaro Yamaguchi ; Hiroko Seki ; Tsutomu Ishikawa
• 刊名：Tetrahedron
• 出版年：2007
• 期刊代码：107_00404020
• 类别：ch
• 出版时间：11 June 2007
• 卷：63
• 期：24
• 页码：5189-5199
• 文件大小：560 K

摘要

The first total synthesis of the proposed structure for methyl-kinamycin C (methyl-KC), derived from KC, was achieved via two key steps: Diels–Alder reaction of benzindenone and Danishefsky-type diene, and the stereoselective construction of highly oxygenated D ring. Good accordance of the spectral data of synthesized title compound with those of natural KC and its derivative was observed.