A report on anti-oedemogenic activity of Byttneria herbacea roots - Possible involvement of histamine receptor (type I)

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• 作者：Lipi Sarkar^a ; N. Bhuvaneswari^a ; Samir K. Samanta^a ; Md. Nurul Islam^b ; Tuhinadri Sen^a ; Hiroyuki Fukui^b ; Hiroyuki Mizuguchi^b ; Sanmoy Karmakar^a ; ^b ; ^{sanmoykarmakar@gmail.com} ; ^{sanmoykar_2006@yahoo.co.in}
• 关键词：HBH ; hydroalcoholic root extract of Byttneria herbacea ; H1R ; human histamine receptor type I ; VEGF ; vascular endothelial growth factor ; LPS ; lipopolysaccharide ; HepG2 ; human hepatocellular liver carcinoma cell line ; MTT ; 3(4 ; 5-dimethylthiazol-2-yl)-2 ; 5-di
• 刊名：Journal of Ethnopharmacology
• 出版年：2012
• 期刊代码：26_03788741
• 类别：pha
• 出版时间：27 March, 2012
• 卷：140
• 期：2
• 页码：443-446
• 文件大小：217 K

摘要

Ethnopharmacological relevance

The traditional healers of the Kol tribes of West Bengal, Bihar and Jharkhand (India), widely use the woody rootstock of Byttneria herbacea to reduce the swelling of limbs, due to filariasis. Besides filariasis different part of this plant is used for the treatment of cholera, diarrhoea and asthma.

Aim of this study

This study is a preliminary attempt to evaluate the anti-oedemogenic activity of the roots of Byttneria herbacea.

Materials and methods

The anti-oedemogenic activity of the hydroalcoholic extract of the roots of Byttneria herbacea (HBH) was evaluated against carrageenan and histamine induced rat paw oedema, acetic acid induced writhing and histamine induced vascular permeability in mice. Further, the effect of HBH on the expression of human histamine receptor type I (H1R) was studied in HeLa cells.

Results

HBH exhibited significant dose-dependent inhibition (*p < 0.05) against carrageenan and histamine induced rat paw oedema. Similar significant dose-dependent inhibition was observed against acetic acid induced writhing and histamine-induced vascular permeability in mice. Moreover, H1R specific mRNA expression was also significantly (*p < 0.05) suppressed by HBH.

Conclusion

HBH was observed to possess anti-oedemogenic activity which is probably mediated through suppression of H1R.