- 作者：Masahiko Shigemura ; Takanori Moriyama ; Hitoshi Shibuya ; Masato Obara ; Tomoyuki Endo ; Satoshi Hashino ; Hiroshi Yokouchi ; Masahiro Asaka ; Chikara Shimizu ; Hitoshi Chiba ; et al.
- 关键词：Multiple myeloma ; Sialyl salivary-type amylase ; Amylase
- 刊名：Clinica Chimica Acta
- 出版年：2007
- 期刊代码：54_00098981
- 类别：med
- 出版时间：1 February 2007
- 卷：376
- 期：1-2
- 页码：121-125
- 文件大小：294 K
There have been several reports describing a notable hyperamylasaemia in patients with multiple myeloma. Such amylase-producing myelomas have been mainly described in the context of concomitant salivary-type hyperamylasaemia, with sialyl salivary-type amylase identified in a portion of those cases. We investigated the incidence of the production of sialyl salivary-type amylase in serum of multiple myeloma patients.
Methods
Eleven patients (6 male and 5 female) who had been diagnosed as having multiple myeloma were enrolled in this study. Sialyl salivary-type amylase was detected by isoamylase electrophoresis and HPLC analysis, and identified by detecting either abnormal neuraminidase-sensitive band through isoamylase electrophoresis or abnormal extra-elution peak of amylase by means of HPLC analysis.
Results
Sialyl salivary-type amylase was detected in 7 out of 11 (63.6%) patients. Median total amylase activity was 154 U/l (range 109–43020). Isoamylase electrophoretic patterns of patients' serum were normal in 5 patients (71.4%) out of 7 patients and salivary-dominant in 2 (50.0%) out of 4 patients.
Conclusions
We consider that there is no significant relationship between total serum amylase level and amylase isoenzyme pattern in the incidence of production of sialyl salivary-type amylase with multiple myeloma.