伪-Santalol derivatives from Santalum album and their cytotoxic activities

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• 作者：Yukiko Matsuo ; ^{matsuoy@toyaku.ac.jp} ; Yoshihiro Mimaki ; ^{mimakiy@toyaku.ac.jp}
• 关键词：Santalum album ; Santalaceae ; Sesquiterpene ; 伪-Santalol ; HL-60 cells ; Cytotoxicity
• 刊名：Phytochemistry
• 出版年：2012
• 期刊代码：85_00319422
• 类别：ch
• 出版时间：May, 2012
• 卷：77
• 期：Complete
• 页码：304-311
• 文件大小：611 K

摘要

A bioassay-guided fractionation of the heartwood of Santalum album led to the isolation of seven 伪-santalol derivatives including (9S,10E)-9-hydroxy-伪-santalal, (10R,11S)-10,11-dihydroxy-伪-santalol, (9E)-11,13-dihydroxy-伪-santalol, and (10E)-12-hydroxy-伪-santalic acid. Their structures were determined on the basis of results of spectroscopic analysis, including two-dimensional (2D) NMR spectroscopic data. The isolated compounds and derivatives were evaluated for cytotoxicity against HL-60 human promyelocytic leukemia cells and TIG-3 normal human diploid fibroblasts. Of these (9S,10E)-9-hydroxy-伪-santalal, exhibited tumor-selective cytotoxicity. The apoptosis induction properties of sesquiterpenes with cytotoxic potency in HL-60 cells are also described.