Study on cytotoxicity and structure-activity relationship of HL-7702 cell exposed to naphthoquinones

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• 作者：Jing Guo^a ; Wenhua Song^a ; ^c ; ^{songwenhua9316@sina.com} ; Feng Ding^b ; Jinyang Zhang^c ; Zengtian Sun^a
• 关键词：Naphthoquinone ; HL-7702 cell ; Cellular viability ; Restoration ; Structure&ndash ; activity relationship
• 刊名：Environmental Toxicology and Pharmacology
• 出版年：2012
• 期刊代码：13_13826689
• 类别：pha
• 出版时间：May, 2012
• 卷：33
• 期：3
• 页码：408-413
• 文件大小：829 K

摘要

The acute cytotoxicities of six naphthoquinone compounds, including Atovaquone, Buparvaquone, Menadione, 2-acetoxy-1,4-naphthoquinone and 2-ethoxy-1,4-naphthoquinone, to HL-7702 cells were determined. The results showed that the toxicities of these naphthoquinones were characterized by a steep response pattern except for 2-hydroxy-1,4-naphthoquinone. Meanwhile, the cellular injuries were unrecoverable. Several molecular descriptors, such as the octanol-water partition coefficients (Log P), diameter (Dia) and topological index (TIndx), played an important role in the toxicity of naphthoquinones to HL-7702 cell. Our results provide a foundation for further investigation using 3D-QSAR and HQSAR to evaluate the aquatic ecological risk and the possible mechanisms of toxicity of naphthoquinones.