Synthesis and characterization of (ethylenediamine)/(diammine)platinum(II) coordinated to seleno ligands containing carboxylic acid functionality

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• 作者：Suresh M. Chopade ; Prasad P. Phadnis ; Amey Wadawale ; Ananda S. Hodage ; Vimal K. Jain ; ^{jainvk@apsara.barc.ernet.in} ; ^{jainvk@barc.gov.in}
• 关键词：Platinum ; Selenoethers ; Diselenides ; NMR ; X-ray structure
• 刊名：Inorganica Chimica Acta
• 出版年：2012
• 期刊代码：40_00201693
• 类别：ch
• 出版时间：30 April, 2012
• 卷：385
• 期：Complete
• 页码：185-189
• 文件大小：426 K

摘要

The reaction of [Pt(N^N)(ONO₂)₂] with seleno ethers, Se{(CH₂)_nCOOH)}₂ (n = 1 or 2) in the presence of NaOH afforded complexes of composition [Pt(N^N)(OOC(CH₂)_nSe(CH₂)_nCOOH)][OH] (N^N = en or 2NH₃; n = 1 or 2). Similar reactions with diselenides, [Se(CH₂)_nCOOH]₂ gave complexes of the type [Pt(en){OOC(CH₂)_nSe}₂]. These complexes were characterized by microanalyses and NMR spectroscopy (¹H, ¹³C{¹H}, ⁷⁷Se{¹H} and ¹⁹⁵Pt{¹H}). The seleno ligand in [Pt(N^N)(OOC(CH₂)_nSe(CH₂)_nCOOH)][OH] is coordinated to platinum through one carboxylate group and a selenium atom. The molecular structure of [Pt(en)(OOCCH₂SeCH₂COOH)][OH] was established by single crystal X-ray diffraction analysis. The reactivity of [Pt(N^N)(OOC(CH₂)_nSe(CH₂)_nCOOH)][OH] with mononucleotide 5鈥?guanosine monophosphate (5鈥?GMP) has been studied in aqueous solution by ¹⁹⁵Pt{¹H} NMR spectroscopy.