Biotin-dependent regulation of gene expression in human cells
- 作者：Alfonso Leó ; n-Del-Rí ; o
- 关键词：Biotin ; Holocarboxylase synthetase ; Carboxylase ; Vitamin utilization ; Gene expression
- 刊名：Journal of Nutritional Biochemistry
- 出版年：2005
- 期刊代码：70_09552863
- 类别：abs
- 出版时间：2005
- 卷：16
- 期：7
- 页码：432-434
- 文件大小：79 K
摘要
The role of biotin as cofactor of carboxylases and its importance in metabolic homeostasis are well known. In recent years, different researchers have suggested the participation of biotin as a regulator molecule in the control of gene expression. Biotin-dependent gene expression requires of the transformation of biotin into biotinyl-5′-AMP by holocarboxylase synthetase and the activation of soluble guanylate cyclase and a cGMP-dependent protein kinase. The regulatory role of biotin is responsible for the correct expression of enzymes involved in biotin utilization in human cells. We propose that this mechanism protects the brain from biotin deficiency.