Interference of Frizzled 1 (FZD1) reverses multidrug resistance in breast cancer cells through the Wnt/尾-catenin pathway

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• 作者：Hui Zhang ^{huizhang2576@gmail.com} ; Xiaofang Zhang ^{zdpxf2317@yahoo.cn} ; Xiaojuan Wu ^{xiaojuanwu0709@163.com} ; Weiwei Li ^{liweiweizhao@163.com} ; Peng Su ^{supeng820125@163.com} ; Hongxia Cheng ^{wormhy@163.com} ; Lei Xiang ^{xianglei1977@163.com} ; Peng Gao ^{gaopeng@sdu.edu.cn} ; Gengyin Zhou ; ^{zhougy@sdu.edu.cn}
• 关键词：Breast cancer ; Multidrug resistance ; MDR1 ; FZD1 ; Wnt/尾-catenin
• 刊名：Cancer Letters
• 出版年：2012
• 期刊代码：44_03043835
• 类别：med
• 出版时间：1 October, 2012
• 卷：323
• 期：1
• 页码：106-113
• 文件大小：1274 K

摘要

Multidrug resistance (MDR) represents a major obstacle in the successful treatment of breast cancer. The MDR1 gene is a direct target of the Wnt/尾-catenin signaling pathway, which controls tumor development. Overexpression of P-glycoprotein, encoded by the MDR1 gene, is one of the most common causes of MDR. We found that the Frizzled 1 (FZD1) protein, which is an essential component of the Wnt/尾-catenin pathway, is overexpressed in the multidrug resistant breast cancer cell subline MCF-7/ADM, coincident with MDR1/P-gp. FZD1 silencing induced down-regulation of MDR1/P-gp, restored sensitivity to four chemotherapy drugs, and significantly decreased cytoplasmic and nuclear 尾-catenin levels. FZD1 appears to mediate multidrug resistance by regulating the Wnt/尾-catenin pathway.