HIF1a expression in bronchial biopsies correlates with tumor microvascular saturation determined using optical spectroscopy

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• 作者：J.G.J.V. Aerts ; A. Amelink ; C. van der Leest ; J.P.J.J. Hegmans ; A. Hemmes ; B. den Hamer ; H.C.J.M. Sterenborg ; H.C. Hoogsteden ; B.N. Lambrecht
• 关键词：Lung cancer ; Hypoxia ; Spectroscopy
• 刊名：Lung Cancer
• 出版年：2007
• 期刊代码：187_01695002
• 类别：med
• 出版时间：September 2007
• 卷：57
• 期：3
• 页码：317-321
• 文件大小：174 K

摘要

Tumor hypoxia is generally considered to be related to aggressive behaviour of a tumor. As in lung cancer direct determination of oxygenation is difficult, hypoxia-related proteins have been studied. A number of studies on these proteins show different results and the usefulness of these protein expressions remains questionable. In this article, we relate one of these hypoxia-related proteins (hypoxia-inducible factor, HIF1a) to a direct in vivo spectroscopic measurement of tumor blood saturation performed during bronchoscopy.

Seventeen samples from malignancies and non-malignant tissues were studied. Microvascular saturation levels in the no malignancy group equalled 87 ± 11.5%(range 71–100%) and in the malignant group 43 ± 21%(range 6–63%). This difference was statistically significant (p c; 0.0002). There was a significant difference in the spectroscopically determined saturations between the biopsies with negative expression of HIF1a and the biopsies with positive expression of HIF1a (p c; 0.005).

From these data, it can be concluded that HIF1a expression is related to a low microvascular blood saturation as determined in vivo by optical spectroscopy. This study may lead to a better acceptance of the usage of different techniques to establish hypoxia in order to study the effect of hypoxia on therapeutic interventions and prognosis of lung cancer.