New approaches to in vitro models of blood–brain barrier drug transport
- 作者：Terasaki ; Tetsuya ; Ohtsuki ; Sumio ; Hori ; Satoko ; Takanaga ; Hitomi ; Nakashima ; Emi ; Hosoya ; Ken-ichi
- 关键词：Blood-brain barrier ; Blood-cerebrospinal fluid barrier ; conditionally immortalized cell line ; brain capillary endothelial cell ; drug permeability ; transporter ; in vitro blood-brain barrier model ; co-culture ; drug delivery to the brain ; CNS drug discovery
- 刊名：Drug Discovery Today
- 出版年：2003
- 期刊代码：29_13596446
- 类别：imm
- 出版时间：October 15, 2003
- 卷：8
- 期：20
- 页码：944-954
- 文件大小：136 K
摘要
The pharmaceutical industry has been searching for an in vitro blood-brain barrier (BBB) model but no one has yet developed one that is workable. Conditionally immortalized cell lines are the best model for the BBB permeable drug discovery today.