Effectiveness of hand hygiene and provision of information in preventing influenza cases requiring hospitalization

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• 作者：Pere Godoy^a ; ^b ; ^c ; ^{Pere.godoy@gencat.cat} ; Jesú ; s Castilla^d ; ^b ; Miguel Delgado-Rodrí ; guez^e ; ^b ; Vicente Martí ; n^f ; ^b ; Nú ; ria Soldevila^b ; Jordi Alonso^g ; ^b ; Jenaro Astray^h ; Maretva Baricot^b ; Rafael Cantó ; nⁱ ; ^b ; Ady Castro^j ; Fernando Gonzá ; lez-Candelas^k ; ^b ; José ; Marí ; a Mayoral^l ; José ; Marí ; a Quintana^m ; ^b ; Tomá ; s Pumarolaⁿ ; Sonia Tamames^o ; Angela Domí ; nguez^p ; ^b ; the CIBERESP Cases ; Controls in Pandemic Influenza Working Group ; Spain¹
• 关键词：Influenza ; Non-pharmacological measures ; Hand hygiene ; Handwashing ; Transmission ; Hospitalization ; Prevention ; Case control study ; Epidemiology
• 刊名：Preventive Medicine
• 出版年：2012
• 期刊代码：306_00917435
• 类别：med
• 出版时间：June, 2012
• 卷：54
• 期：6
• 页码：434-439
• 文件大小：186 K

摘要

Background

The objective of the study was to investigate the effectiveness of non-pharmacological interventions in preventing cases of influenza requiring hospitalization.

Methods

We performed a multicenter case-control study in 36 hospitals, in 2010 in Spain. Hospitalized influenza cases confirmed by reverse-transcription polymerase chain reaction and three matched controls (two hospital and one community control) per case were selected. The use of non-pharmacological measures seven days before the onset of symptoms (frequency of hand washing, use of alcohol-based hand sanitizers and handwashing after touching contaminated surfaces) was collected.

Results

We studied 813 cases hospitalized for influenza and 2274 controls. The frequency of hand washing 5-10 times (adjusted odds ratio [aOR] = 0.65) and > 10 times (aOR = 0.59) and handwashing after contact with contaminated surfaces (aOR = 0.65) were protective factors and were dose-responsive (p < 0.001). Alcohol-based hand sanitizers were associated with marginal benefits (aOR = 0.82).

Conclusions

Frequent handwashing should be recommended to prevent influenza cases requiring hospitalization.