Evaluation of the effect of chronic exposure to ¹³⁷Cesium on sleep–wake cycle in rats

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• 作者：Philippe Lestaevel ; Bernadette Dhieux ; Elie Tourlonias ; Pascale Houpert ; Franç ; ois Paquet ; Philippe Voisin ; Jocelyne Aigueperse and Patrick Gourmelon
• 刊名：Toxicology
• 出版年：2006
• 期刊代码：47_0300483x
• 类别：pha
• 出版时间：21 September 2006
• 卷：226
• 期：2-3
• 页码：118-125
• 文件大小：169 K

摘要

Since the Chernobyl accident, the most significant problem for the population living in the contaminated areas is chronic exposure by ingestion of radionuclides, notably ¹³⁷Cs, a radioactive isotope of cesium. It can be found in the whole body, including the central nervous system. The present study aimed to assess the effect of ¹³⁷Cs on the central nervous system and notably on open-field activity and the electroencephalographic pattern. Rats were exposed up to 90 days to drinking water contaminated with ¹³⁷Cs at a dosage of 400 Bq kg⁻¹, which is similar to that ingested by the population living in contaminated territories. At this level of exposure, no significant effect was observed on open-field activity. On the other hand, at 30 days exposure, ¹³⁷Cs decreased the number of episodes of wakefulness and slow wave sleep and increased the mean duration of these stages. At 90 days exposure, the power of 0.5–4 Hz band of ¹³⁷Cs-exposed rats was increased in comparison with controls. These electrophysiological changes may be due to a regional ¹³⁷Cs accumulation in the brain stem. In conclusion, the neurocognitive effects of ¹³⁷Cs need further evaluation and central disorders of population living in contaminated territories must be considered.