Trichalasins C and D from the plant endophytic fungus Trichoderma gamsii

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• 作者：Gang Ding^a ; ^{dgfyhchina@163.com} ; Lin Chen^a ; Amandajuan Chen^a ; Xinhui Tian^a ; Xiangdong Chen^a ; Hongwu Zhang^a ; Hong Chen^b ; Xing-Zhong Liu^c ; Yonggang Zhang^d ; Zhong-Mei Zou^a ; ^{zmzou@implad.ac.cn}
• 关键词：Trichalasins C and D ; Cytotoxicity ; Endophytes ; Trichoderma gamsii ; Structure elucidation
• 刊名：Fitoterapia
• 出版年：2012
• 期刊代码：35_0367326x
• 类别：ch
• 出版时间：April, 2012
• 卷：83
• 期：3
• 页码：541-544
• 文件大小：345 K

摘要

Two new cytochalasans, trichalasins C (1) and D (2) together with known cytochalasans aspochalasins D (3), M (4) and P (5) were isolated from one endophytic fungus Trichoderma gamsii inhabiting in traditional medicinal plant Panax notoginseng (BurK.) F.H.Chen. The structures for the new compounds 1 and 2 were determined by NMR and HRESIMS, and their relative configurations were established by analysis of coupling constants and NOESY correlations. Compound 3 displaying inhibitory activity with EC₅₀ value 5.72 渭M, whereas the EC₅₀ values for compounds 1, 2 and 4, 5 are more than 40 渭M.