摘要
Six new trace sesquiterpenes, corialactones A-D (1-4), coriantone (5), corianol (6), together with nine known ones (7-15), were isolated from the roots of Coriaria nepalensis. The structures of 1-6 were elucidated through a combination of extensive NMR spectroscopic analysis, HRESIMS, CD, Rh2(OCOCF3)4-induced CD, Snatzke's method, and X-ray crystallography. Compounds 2-4, and 6 possess characteristic structural units compared with the previously reported sesquiterpenes from this family. In聽vivo system, compounds 5, 6 and 10 showed anti-convulsant activity by 20%, 60%, and 20%at the dose of 5聽mg/kg, respectively.