Improved targeting of 5-[¹²⁵I/¹³¹I]iodo-2′-deoxyuridine to rat hepatoma by using lipiodol emulsion

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• 作者：Hung-Man Yu ; Hsin-Pei Yeh ; Tien-Kui Chang ; Kuang-Liang Huang ; Kuo-Tang Chuang ; Ren-Shen Liu ; Shyh-Jen Wang ; Jeng-Jong Hwang ; Kwan-Hwa Chi ; Fu-Du Chen ; et al.
• 关键词：Hepatoma ; Iododeoxyuridine ; Auger electron ; Lipiodol ; Radionuclide therapy
• 刊名：Nuclear Instruments and Methods in Physics Research Section A ; Accelerators ; Spectrometers ; Detectors and Associated Equipment
• 出版年：2006
• 期刊代码：41_01689002
• 类别：ph
• 出版时间：20 December 2006
• 卷：569
• 期：2
• 页码：538-542
• 文件大小：471 K

摘要

This study aims to assess whether emulsion of [^125/131I]IUdR and lipiodol (IUdR/LP) can improve delivery of IUdR into hepatoma.

Methods

In vitro release profile of IUdR from IUdR/LP to serum was performed. IUdR/LP was injected into N1-S1 hepatoma-bearing SD rat via hepatic artery and IUdR/normal saline (IUdR/NS) was used for comparison. Biodistribution, autoradiography, imaging and tumor DNA incorporation assay were performed. The radioactive metabolites in plasma and urine were analyzed. Radiation doses to tumor and organs were estimated.

Results

IUdR released from lipiodol into serum was fast. There were longer retention, more DNA incorporation and higher radiation dose of IUdR in the tumor by using IUdR/LP. IUdR/LP deposited deep in the hepatomas. Only free iodide was found in the plasma and urine after injection of IUdR/LP.

Conclusions

Hepatic artery injection of IUdR/LP emulsion could definitely enhance the tumor cell uptake and incorporation to DNA of *IUdR, prolong the tumor retention time and increase radiation dose to tumor. IUdR/LP may be an effective therapeutic agent for the treatment of hepatic tumors.