Serotonin gene polymorphisms and psychiatry comorbidities in temporal lobe epilepsy

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• 作者：Laila Cigana Schenkel^a ; ^b ; ^c ; José ; Augusto Bragatti^b ; ^c ; ^d ; Juliana Allebrand Becker^a ; Carolina Machado Torres^b ; ^c ; ^d ; Kelin Cristine Martin^c ; ^d ; Ana Claudia de Souza^c ; ^d ; Gisele Gus Manfro^c ; ^e ; Sandra Leistner-Segal^a ; ^c ; Marino Muxfeldt Bianchin^b ; ^c ; ^d ; ^{mmbianchin@hotmail.com}
• 关键词：Epilepsy ; Serotoninergic system ; 5-HTT ; 5-HT1A ; Mood disorders
• 刊名：Epilepsy Research
• 出版年：2012
• 期刊代码：87_09201211
• 类别：med
• 出版时间：May, 2012
• 卷：99
• 期：3
• 页码：260-266
• 文件大小：250 K

摘要

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Summary

Objective

Neuropsychiatric comorbidities are frequent in temporal lobe epilepsy (TLE). It is biologically plausible that alterations in serotonin-related genes may be involved in higher susceptibility to psychiatric disease in these individuals. Here we report results of an association study of serotonin gene polymorphisms and psychiatry comorbidities in TLE.

Methods

Case-control study of 155 patients with temporal lobe epilepsy. We evaluate the influence of 5-HTTLPR and 5-HTTVNTR polymorphisms in the 5-HTT gene and the C-1019G polymorphism in the 5-HT1A gene in psychiatric comorbidities of TLE.

Results

After logistic regression, female sex (OR = 2.34; 95%CI 1.06-5.17; p = 0.035) and the presence of C allele of 5-HT1A C-1019G polymorphism (OR = 2.77; 95%CI 1.01-7.63; p = 0.048) remained independent risk factors for anxiety disorders in temporal lobe epilepsy.

Conclusion

C allele of 5-HT1A C-1019G polymorphism might be an independent risk factor for anxiety disorders in temporal lobe epilepsy. We believe that other studies in this venue will shade some light on molecular mechanisms involved in psychiatric comorbidities in epilepsy.