- 作者：Qianqian Wang ; Xiaohua Liang ; Laiyuan Wang ; Xiangfeng Lu ; Jianfeng Huang ; Jie Cao ; Hongfan Li ; Dongfeng Gu ; gudf@yahoo.com
- 关键词：Omega-3 fatty acids ; Endothelial function ; Meta-analysis
- 刊名：Atherosclerosis
- 出版年：2012
- 期刊代码：28_00219150
- 类别：med
- 出版时间：April, 2012
- 卷：221
- 期：2
- 页码：536-543
- 文件大小：739 K
Objective
Inverse association was reported between omega-3 fatty acids (FAs) supplementation and the risk of cardiovascular disease. Identifying the effect of omega-3 FAs on endothelial function may contribute to explain the association. We conducted a meta-analysis to assess the effect of omega-3 FAs supplementation on endothelial function, as measured by flow-mediated dilation (FMD) and endothelium-independent vasodilation (EIV).Methods
Randomized placebo-controlled trials (RCTs) were identified from the databases of PubMed, EMBASE and Cochrane library by two investigators and the pooled effects were measured by weighted mean difference (WMD), together with 95%confidence intervals (CIs). Subgroup and meta-regression analyses were used to explore the source of between-study heterogeneity.
Results
Totally 16 eligible studies involving 901 participants were finally included in meta-analysis. Compared with placebo, omega-3 FAs supplementation significantly increased FMD by 2.30%(95%CI: 0.89-3.72%, P = 0.001), at a dose ranging from 0.45 to 4.5 g/d over a median of 56 days. Subgroup analyses suggested that the effect of omega-3 FAs on FMD might be modified by the health status of the participants or the dose of supplementation. Sensitivity analyses indicated that the protective effect of omega-3 on endothelial function was robust. No significant change in EIV was observed after omega-3 FAs supplementation (WMD: 0.57%; 95%CI: 鈭?.88 to 2.01%; P = 0.442).
Conclusion
Supplementation of omega-3 fatty acids significantly improves the endothelial function without affecting endothelium-independent dilation.