The lepidolite was pre-roasted at a high temperature with water steam atmosphere for defluorination. Then the defluorinated lepidolite was leached in a lime-milk autoclave. Various parameters including the defluorination percentage of lepidolite, milling time, temperature, time, lime-to-defluorinated lepidolite ratio, and liquid-to-solid ratio in the leaching process were optimized. The lithium extraction efficiency can reach 98.9%under the optimal conditions. The purity of the lithium carbonate obtained can be up to 99.9%.