Triterpenoidal saponins from Hydrocotyle sibthorpioides

详细信息	查看全文 | 推荐本文 |

• 作者：Hui-Chi Huang ; Chia-Ching Liaw ; Li-Jie Zhang ; Hsi-Uo Ho ; Li-Ming Yang Kuo ; Ya-Ching Shen ; Yao-Haur Kuo
• 关键词：Hydrocotyle sibthorpioides ; Umbelliferae ; Oleanane-type triterpenoidal saponin ; Cytotoxicity ; Chemotaxonomy
• 刊名：Phytochemistry
• 出版年：2008
• 期刊代码：85_00319422
• 类别：ch
• 出版时间：May 2008
• 卷：69
• 期：7
• 页码：1597-1603
• 文件大小：150 K

摘要

Oleanane-type triterpenoidal saponins, hydrocosisaponins A–F (1–6), along with a known saponin, hydrocotyloside VII (7), were isolated from Hydrocotyle sibthorpioides. Their structures were established on the basis of spectroscopic analyses including NMR spectroscopic techniques (¹³C, ¹H, COSY, HMQC, HMBC, TOCSY and NOESY). Biological evaluation established that saponins possessing four sugar units (three d-glucoses and one l-arabinose) (4–7) exhibited moderate cytotoxicity against KB, Daoy and WiDr human tumor cell lines.