Increased c-Fos expression in the medial part of the lateral habenula during cue-evoked heroin-seeking in rats
- 作者：Fuqiang Zhang ; Wenhua Zhou ; Huifen Liu ; Huaqiang Zhu ; Shuaien Tang ; Miaojun Lai and Guodong Yang
- 关键词：c-Fos ; Lateral habenula ; Heroin ; Cue ; Drug seeking
- 刊名：Neuroscience Letters
- 出版年：2005
- 期刊代码：52_03043940
- 类别：neu
- 出版时间：2005
- 卷：386
- 期：2
- 页码：133-137
- 文件大小：161 K
摘要
Conditioned environmental stimuli are known to be important determinants of drug seeking behavior. c-Fos, the protein product of the protooncogene c-Fos, is expressed in neurons when there are drug-associated cue-induced drug-seeking behaviour. Therefore, its expression could serve as a marker of regional neuronal activation. Using an extinction/reinstatement paradigm of relapse animal model, we trained Sprague-Dawley rats to nose-poke for i.v. heroin (0.05 mg/kg/infusion) either daily for 4 h or 25 infusions for 14 consecutive days. We then tested these animals for cue-evoked heroin-seeking behavior after abstinence from self-administration of heroin for 14 days. Expression of c-Fos was examined in the lateral habenula (LHb), a region important for conveying information between the limbic forebrain and midbrain. Findings showed that heroin-associated conditioned stimuli could induce robust heroin-seeking behavior that was associated with increased c-Fos immunoreactivity in the medial part of the LHb. This observation suggests the involvement of the LHb in mediating drug cue-induced heroin-seeking behavior after abstinence from self-administration of heroin.