Pharmacological specificity of the discriminative stimulus effects of Δ⁹-tetrahydrocannabinol in rhesus monkeys

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• 作者：Wiley ; Jenny L. ; Huffman ; John W. ; Balster ; Robert L. ; Martin ; Billy R.
• 关键词：Δ ; ⁹-tetrahydrocannabinol ; WIN 55212-2 ; CNS depressants ; Indoles ; Drug discrimination
• 刊名：Drug and Alcohol Dependence
• 出版年：1995
• 期刊代码：81_03768716
• 类别：med
• 出版时间：November, 1995
• 卷：40
• 期：1
• 页码：81-86
• 文件大小：582 K

摘要

Δ⁹-Tetrahydrocannabinol (Δ⁹-THC) discrimination has been used as an animal model of cannabis intoxication in humans. While numerous studies have examined the discriminative stimulus effects of cannabinoids in rats and pigeons, studies with monkeys have been rare. In the present study, rhesus monkeys, trained to discriminate Δ⁹-THC from vehicle in a two-lever drug discrimination procedure, were tested with a variety of psychoactive drugs, including cannabinoids as well as drugs from other classes. Results showed that Δ⁹-THC discrimination showed pharmacological specificity, in that none of the non-cannabinoid drugs fully substituted for Δ⁹-THC. In contrast, the classical cannabinoids, Δ⁹-THC and Δ⁸-THC, and the novel cannabinoids, WIN 55212-2 and 1-butyl-2-methyl-3-(1-naphthoyl)indole, produced full dose-dependent substitution for Δ⁹-THC in all monkeys. A heptyl indole derivative failed to substitute for Δ⁹-THC, but it also did not displace [³H] CP 55940 from its binding site. These findings are consistent with those of previous cannabinoid discrimination studies with rats and suggest that results of Δ⁹-THC discrimination studies in rhesus monkeys may be predictive of the subjective effects of cannabinoid drugs in humans.